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Silvia Simeoni

CURRICULUM VITAE

Dr. Silvia SIMEONI


silvia.simeoni@uniroma1.it

PROFESSIONAL EXPERIENCE

2010-2012

Post-doc fellowship, team of Prof. Anna Tramontano, University of Rome, “La Sapienza”.

Department of Physics

  • Design of new antimalarial and antischistosomal agents

2007 -09

Istituto Pasteur - Fondazione Cenci Bolognetti fellowship, team of Prof. Antonello Mai and Dr. Rino Ragno, University of Rome, “La Sapienza”.

Department of “Chimica e tecnologie del farmaco”

  • Design of chromatin-modifying agents using molecular modeling tools

2004-2006

AIRC fellowship, team of Prof. Antonello Mai and Dr. Rino Ragno, University of Rome, “La Sapienza”.

Department of “Chimica e tecnologie del farmaco”

  • 3D-QSAR, Ligand/Structure Based Drug Design and Molecular Dynamics and Docking

2000-2003

PhD student, team of Prof. Santo Scalia, University of Ferrara.

Department of Pharmaceutical Sciences

  • Studies of sun filters photostability, free and complexed by cyclodextrins

2002

PhD student, team of Prof. Heather Benson, Curtin University, Perth Australia.

School of Pharmacy

  • Studies of percutaneous absorption

1998-1999

Microbiological and Technology Research, Kelemata S.p.a cosmetic industry, Martellago (VE).

Microbiological and technological research laboratories

1997

Pratical Training in the pharmacy of Sant'Orsola hospital.

ACADEMIC ACTIVITIES

2010

Pharmaceutical chemistry course at Bioinformatics Master

2005-2008

Member of Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci” and e “Chimica Farmaceutica e Tossicologica I” exam commissions

Molecular Modeling courses

EDUCATION

2000-2004

Ph.D in Pharmaceutical Sciences - section “Cosmetic Sciences and Tecnologies”, University of Siena, Italy.

1998-2000

Master in Cosmetic Sciences and Tecnologies, University of Ferrara, Italy.

With full marks and honors

 

1991-1997

Degree in Chemistry and Pharmaceutical Technologies at Bologna University.

Final Mark: 109/110

 

LANGUAGES

 

english, fluent

french, good comprehension

INFORMATICS

 

Windows and Unix/Linux

 

PUBBLICATIONS

1)Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition”. Caroli A, Simeoni S, Lepore R, Tramontano A, Via A. Biochem Biophys Res Commun, 417(1):576-81:2012.

2)Identification of the Schistosoma mansoni Molecular Target for the Antimalarial Drug Artemether”. Lepore R, Simeoni S, Raimondo D, Caroli A, Tramontano A, Via A. J Chem Inf Model. 51(11):3005-16, 2011.

3)Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity”. Sergio Valente, Maria Tardugno, Mariarosaria Conte, Roberto Cirilli, Andrea Perrone, Rino Ragno, Silvia Simeoni, Silvio Massa, Angela Nebbioso, Marco Miceli, Gianluigi Franci, Gerald Brosch,[e] Lucia Altucci, and Antonello Mai. ChemMedChem,6 (4):698-712,2011.

4)Design, Synthesis and Biological Evaluation of Carboxy- Analogues of arginine methyltransferase inhibitor 1 (AMI-1)”. Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Bedford M T and Sbardella G. ChemMedChem, 5(3): 398-414, 2010.

5) Small-Molecule Interferon Inducers. Toward the Comprehension of the Molecular Determinants through Ligand-Based Approaches (dagger).” Musmuca I, Simeoni S, Caroli A, Ragno R. J Chem Inf Model,49(7):1777-86, 2009.

6) “New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations”. Mai A, Valente S, Nebbioso A, Simeoni S, Ragno R, Massa S, Brosch G, De Bellis F, Manzo F, Altucci L. Int J Biochem Cell Biol., 41(1): 235-47, 2009.

7) “Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR, homology and docking studies”. Ragno R, Simeoni S, Rotili D, Caroli A, Botta G, Brosch G, Massa S, Mai A. Eur J Med Chem., 43(3):621-32, 2008.

8) “Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains”. Mai A, Artico M, Rotili D, Tarantino D, Clotet-Codina I,Armand-Ugon M, Ragno R, Simeoni S, Sbardella G, Nawrozkij MB, Samuele A, Maga G, Este' JA. J Med Chem, 50, 22, 5412-24, 2007.

9) “Synthesis and Biological Validation of Novel Synthetic Histone/Protein Methyltransferase Inhibitors”. Mai A, Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, Bedford MT. ChemMedChem, 2, 7, 987-991, 2007.

10) “Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations”. Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G. J Med Chem, 50, 6, 1241-53, 2007.

11) “Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors”. Mai A, Massa S, Rotili D, Simeoni S, Ragno R, Botta G, Nebbioso A, Miceli M, Altucci L, Brosch G. J Med Chem, 49, 20, 6046-56, 2006.

12)Aroyl-pyrrolyl hydroxyamides: influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition”. Mai A, Massa S, Valente S, Simeoni S, Ragno R, Bottoni P, Scatena R, Brosch G. ChemMedChem, 1, 2, 225-37, 2006.

13) “3-D QSAR Studies on Histone Deacetylase Inhibitors. A GOLPE/GRID Approach on Different Series of Compounds”. Ragno R, Simeoni S, Valente S, Massa S, Mai A. J Chemical Information and Modeling, 46, 3, 1420-1430, 2006.

14) “Design, Synthesis, and Biological Evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors”. Antonello Mai, Silvio Massa, Siva Lavu, Riccardo Pezzi, Silvia Simeoni, Rino Ragno, Francesca R. Mariotti, Francesco Chiani, Giorgio Camilloni and David A. Sinclair. J. of Medicinal Chemistry, 48, 24, 7789-7795, 2005.

15) “Class II (IIa)-Selective Histone Deacetylase inhibitors. 1.Synthesis and biological evaluation of novel (Aryloxopropenyl)pyrrolyl hydroxyamides”. Antonello Mai, Silvio Massa, Riccardo Pezzi, Silvia Simeoni, Dante Rotili, Angela Nebbioso, Annamaria Sconamiglio, Lucia Altucci, Peter Loidl and Gerald Brosch. J. of Medicinal Chemistry, 48, 9, 3344-3353, 2005.

16) “Histone Deacetylation in epigenetics: an attractive target for Anticancer Therapy”. A.Mai, S.Massa, D.Rotili, I.Cerbara, S.Valente, R.Pezzi, S.Simeoni, R.Ragno. Medicinal research reviews, 25, 3, 261-309, 2005.

17) “Influence of Cyclodextrin Complexation on the in vitro Human Skin Penetration and Retention of the Sunscreen Agent, Oxybenzone”. Simeoni S, Scalia S, Tursilli R, Benson H. J of Inclusion Phenomena and Macrocyclic Chemistry, 54, 3-4, 275-282, 2006.

18) “Assay of common sunscreen agents in suncare products by high-performance liquid chromatography on a cyanopropyl-bonded silica column”. Simeoni S, Tursilli R, Bianchi A, Santo S. J Pharmaceutical and Biomedical Analysis, 38, 2, 250-255, 2005.

19) “Influence of cyclodestrins on in vitro human skin absorption of the sunscreen, butyl-methoxydibenzoylmethane”. S.Simeoni, S.Scalia, H. Benson. International Journal of Pharmaceutics 280, 163-171, 2004.

20) “Effect of nanoparticle encapsulation on the photostability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate”. P.Perugini, S.Simeoni, S.Scalia, I. Genta, T. Modena, B. Conti, F. Pavanetto. International Journal of Pharmaceutics, 246, 37-45, 2002.

21) “Comparative studies of the influence of cyclodextrins on the stability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate”. S. Scalia, A. Casolari, A. Iaconinoto, S. Simeoni. J. Pharmaceutical and Biomedical Analysis , 30,1181-1189, 2002.

22) “Influence of hydroxypropyl-ß-cyclodextrin on photo-induced free radical production by the sunscreen agent , butyl-methoxydibenzoylmethane”. S. Scalia, S. Simeoni, A. Barbieri, S. Sostero. J. Pharmacy and Pharmacology, 54, 1553-1558, 2002.

23)Determination of adenosine A(1) agonist N(6)-cyclopentyladenosine in rat blood by solidphase extraction and HPLC”, S.Scalia, S.Simeoni, A.Dalpiaz, S.Villani; Journal of Pharmaceutical and Biomedical analysis, 24, 1131-1136, 2001.

24)Determination of bronopol in cosmetic products by HPLC with electrochemical detection”. Scalia S, Simeoni S, Bousquet E. Pharmazie, 56, 4, 318-20, 2001.

25) “Assay of xantene dyes in lipsticks by inverse supercritical fluid extraction and HPLC”. S. Scalia, S.Simeoni. Chromatographia, 53, 490-494, 2001.

26) “Influenza della complessazione con ciclodestrine sulla fotostabilita’ di filtri solari”. S.Simeoni, S.Villani, S.Scalia. Kosmetica, 5, 19-24, 2000.

GRANTS

 

2007

Istituto Pasteur- Fondazione Cenci Bolognetti fellowship

 

2001

Young researcher fellowship, Ferrara University

 

Last Updated ( Thursday, 01 March 2012 13:05 )