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Edoardo Milanetti

 

Personal Informations
Name                                           -- Edoardo Milanetti
Address 63, Via A. Manzoni, 00010, Guidonia Montecelio, Italy
Telephone +393396094074
E-mail edoardo(dot)milanetti(at)gmail(dot)com
Nationality Italian
Date of birth                            28, July, 1987

 

CURRENT POSITION

Dates(from)            

-                                                    - November 2015

Position                            

Postdoctoral fellow in Biophysics, Bioinformatics and Computational Biology
Institution               Department of Physics, University "Sapienza" of Rome, P.le Aldo Moro 5, 00185 Rome - Italy
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Study of the antibody thermodynamic stability through statistical approaches for large dataset derived from crystal structure and analysis of the evolution of side chains arrangements in molecular dynamics simulations performed at different temperatures.

Molecular Dynamics simulations and structural studies of antibodies in their Apo and Holo conformations in order to understand the molecular details of antibodies effector function.

Master thesis tutor of physics student, Eugenio Gagliardi: development of a new computational method able to identify intramolecular interactions in a coarse grained protein model. 

 

EDUCATIONAL BACKGROUND

Dates (from-to)    

                        November 2012 - October 2015.
Title of qualification awarded                                                                                                 PhD in Life Science and Bioinformatics, classification: Excellent
Institution "La Sapienza" Univerity of Rome, Italy.
Dissertation "Mapping the hydropathy of amino acids and drugs based on their solvation structure"
Supervisor Anna Tramontano, Professor of Biochemistry, University of Rome "La Sapienza"
Practical training            

Development of a method, in collaboration with the Giovanni Ciccotti group, for the study of chemical and physical characteristics of a compound from a computation point of view.

Study of hydropathy characteristics of twenty natural amino acids through statistical analysis of hydration structure by performing molecular dynamics simulations and prediction study of transmembrane regions. - Study of the passive absorption process of drugs through the cell membrane.

Prediction model for experimental permeability data (Caco-2). Study, at atomic level, of the electric charge distribution, in the chemical structure of drug, in order to improve the prediction quality of the permeation ability and to better understand passive transport mechanisms.

Dates (from-to)

October 2006 - October 2012.
Title of qualification awarded                                                                                                              Laurea in Physics (Biosystems), grade: 110/110
Institution "La Sapienza" Univerity of Rome, Italy.
Dissertation "Analysis of the moonlight type behavior of the CYFIP1 protein through molecular dynamics studies of the dimer CYFIP1-NCK1: importance to autism and schizophrenia"
Supervisor Anna Tramontano, Professor of Biochemistry, University of Rome "La Sapienza"
Practical training

From February 2011 to October 1012, reseacher in the laboratory of the Biocomputing group of the Prof. Anna Tramontano, Professor of Biochemistry, University of Rome "La Sapienza".

Study of conformational change in the protein CYFIP1 through classical molecular dynamics simulation. The protein is of special biological interest because it is involved in the CYFIP1-NCK1 complex: relevance to autism and schizophrenia.  Analysis of the intramolecular interaction  networks  during the evolution of the system and deepening of docking techniques.

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TECHNICAL SKILLS AND COMPETENCES
Operating systems   Linux, OSX , Windows
Informatics tools Latex, Ms Office Package, Open Office, Adobe Acrobat.
Software development Programming languages: C, Fortran90 and R.

Structual biology software  VMD, Chimera, PYMOL
Statistical analysis software     R
Molecular dynamics software  Namd and Gromacs

 

 PUBLICATIONS 

 1) S. Bonella*, D. Raimondo*, E. Milanetti*, A. Tramontano and G. Ciccotti. Mapping the hydropathy of amino acids based on their local solvation structure. Jornal of Physical Chemistry B, 2014 Jun 19.
 2) E. Milanetti, D. Raimondo and A. Tramontano. Prediction of the permeability of neutral drugs inferred from their solvation properties. Bioinformatics, 2015 Dec 10.

 

SEMINARS, CONFERENCES AND WORKSHOPS 

 Organizing Committee: 6th BeMM - Biology and Molecular Medicine PhD Symposium November 30th, 2015 Rome (IT), Policlinico Umberto I of Rome.

 

 Poster Presentation: BITS - Conference of the Italian Society of Bioinformatics February 26th-28th 2014 Rome (IT), “Sapienza” University of Rome, Department of Physics.

 

 Seminar: "Molecular Dynamics simulations and its applications" . June 9th 2014 Rome (IT) , “Sapienza” University of Rome, Department of Chemistry.

 

 Workshops: "Physics of biomolecules: structure, dynamics and function" − February 3th-6th 2016 Bressanone (IT), University of Padova.
Last Updated ( Thursday, 05 May 2016 15:47 )