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Rosalba Lepore

Biocompting Group
Department of Physics 
Sapienza - University of Rome
P.le A. Moro 5 - 00185 Rome - Italy 
Office: +390649694287 


Background in molecular and computational biology with extensive coding experience and analysis of biological data from different data sources. Good knowledge of data management tools and familiarity with high throughput computing environments. Proficiency with data exploration and visualization tools. 


Sapienza Universita` di Roma                                                                                                 Roma, IT
PhD, Computational Biology                                                                                                      Nov 2014
Supervisor: Anna Tramontano
Thesis: From protein structure to interactions to function

Universita` degli studi di Roma Tor Vergata                        Roma, IT 
M.Sc., summa cum laude, Bioinformatics and Computational Biology                                    Oct 2010

Sapienza  Universita` di Roma                                                                                                 Roma, IT
M.Sc., Molecular and Cellular Biology                                                                                      July 2008


OS: Linux/OSX, Windows

Languages: Perl, Python, C

Data analysis: R/Bioconductor, MATLAB


Web: HTML, XML, CSS, PHP, JQuery, Bootstrap

Documentation: LATEX, MS Office


1. R Lepore, PP Olimpieri, MA Messih and A Tramontano PIGSPro: prediction of immunoGlobulin structures v2. Nucleic Acids Res. 2017 May 4. doi: 10.1093/nar/gkx334. 
   2. Di Rienzo L, Milanetti E, Lepore R, Olimpieri PP and Tramontano A. Superposition-freecomparison and clustering of antibody binding sites: implications for the prediction of the nature of their antigen. Scientific Reports 7, 45053   
 3. Jiang Y, Ronnen-Oron T, Clark WT , Bankapur AR, D’Andrea D, Lepore R et al.. An expanded evaluation of protein function prediction methods shows an improvement in accuracy. Genome Biol. 2016 Sep 7;17(1):184  
  4. Obarska-Kosinska A., Iacoangeli A., Lepore R.**, Tramontano A. PepComposer: computational design of peptides binding to a given protein surface. Nucleic Acids Res. 2016 Apr 30 doi: 10.1093/nar/gkw366 
5. Messih M.A., Lepore R., Tramontano A. LoopIng: a template-based tool for predicting the structure of protein loops. Bioinformatics. 2015 Dec 1;31(23):3767-72 doi: 10.1093/bioinformatics/btv438  
 6. Bonome E., Lepore R., Raimondo D., Cecconi F., Tramontano A., Chinappi M. Multistep current signal in protein translocation through graphene nanopores. The Journal of Physical Chemistry B. 2015 May 7;119(18):5815-23 doi10.1021/acs.jpcb.5b02172  
  7. Messih M.A.*, Lepore R.*, Marcatili P.*, Tramontano A. Improving the accuracy of the structure prediction of the third hypervariable loop of the heavy chain of antibodies. Bioinformatics. 2014 Oct;30(19):2733-40 doi: 10.1093/bioinformatics/btu194  
 8. Lepore R., Tramontano A., Via A. TiPs: a database of therapeutic targets in pathogens and associated tools. Bioinformatics. 2013 29(14):1821-2. doi: 10.1093/bioinformatics/btt289 
   9. Pillai D.R., Lau R., Khairnar K., Lepore R., Via A., Staines H.M., Krishna S. Artemether resistance in vitro is linked to mutations in PfATP6 in travellers returning with Plasmodium falciparum infections. Malar J. 2012 Apr 27;11:doi: 10.1186/1475-2875-11-131  
  10. Caroli A., Simeoni S., Lepore R., Tramontano A., Via A. Investigation of a potential mechanism for the inhibition of SmTGR by auranofin and its implications for Plasmodium Falciparum inhibition. Biochem Biophys Res Commun. 2012 Jan 6;417(1):576-81 doi: 10.1016/j.bbrc.2011.12.009  
 11. Lepore R., Simeoni S., Raimondo D., Caroli A., Tramontano A., Via A. (2011) Identification of the Schistosoma mansoni Molecular Target for the Anti Malarial Drug Artemether. J Chem Inf Model. 2011 Nov 28;51(11):3005-16. doi: 10.1021/ci2001764

*equally contributing authors **corresponding author


The Non-Coding Genome: an EpiGeneSys-EPIGEN joint workshop for junior researchers − December 3-4, 2015 Roma (IT)

EPIGEN Workshop: Statistical Analysis of NGS data September 9-11, 2015 Padova (IT)

On Top Of Genetics Workshop: NGS for Epigenetics June 22-23, 2015 Udine (IT)

BeMM Biology and Molecular Medicine PhD Symposium January 23, 2015 Roma (IT)

BITS** Conference of the Italian Society of Bioinformatics February 26-28, 2014 Roma (IT)

KAUST** workshop on quantitative biology: A matter of perspective June 22-24, 2011 Roma (IT)

**Organizing committee 


Last Updated ( Wednesday, 10 May 2017 19:33 )