Name Guido Leoni
e-mail email@example.com; firstname.lastname@example.org
My interests cover several aspects related to the analysis of genome expression with particular attention to the functional role and the regulatory relationships between the products of the alternative splicing.
Recently I'm interested to study under a structural perspective, the ways of miRNA-target interactions.
In the past five years I investigated with several bioinformatic techniques different aspects related to the ability of molecules of nutritional interest to modulate phenotypes related to diseases in animal and cellular models
Dates (from) May 2013
Position Post doc
Institution Sapienza University Physics department Rome-Italy.
Dates (from) September 2008
Position Bioinformatic researcher (collaboration contract)
Institution CRA- NUT Rome-Italy.
Dates September 2007 – September 2008
Position bioinformatic consultant
Company Giuliani farmaceutici s.p.a.
Main activities development of a genotipic platform diagnostic for the individuation of genetic profiles predisposed to an increased risk of pathologies with nutritional components
Dates October 2009-March 2012
Title PhD in Biochemistry
Institution Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P.le Aldo Moro, 5;00185 Rome Italy.
Tutor Prof. Anna Tramontano
Dates October 2004-December 2005
Title Master degree in "Bioinformatics: biomedical and pharmaceutical applications"
Institution Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P.le Aldo Moro, 5;00185 Rome –Italy.
Dates September 1995-April 2003
Title Degree in Chemistry and Pharmaceutical Technologies; grade: 97/110
Institution University of Studies of Bari
Tutor Prof. Antonio Carrieri
4° Microarray analysis course Maastricht(NL) June 10th-15rd (2009) 7° Masterclass in Nutrigenomic Wageningen (NL) September 20th-25rd (2007) 5° Biosapiens 3rd Permanent School in Bioinformatics Madrid (ES) September 19th - 23rd (2005)
PUBLICATIONSLeoni G., Rosato A., Perozzi G., Murgia C. Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies. Genes Nutr. 2014 Nov;9(6):436. Ambra, R., Manca, S., Palumbo, MC., Leoni, G., Natarelli, L., De Marco, A., Consoli, A., Pandolfi, A., Virgili, F.Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression, Genomics (2014) Baima S., Forte V., Possenti M., Peñalosa A., Leoni G., Salvi S., Felici B., Ruberti I., Morelli G., Negative Feedback Regulation of Auxin Signaling by ATHB8/ACL5–BUD2 Transcription Module, Molecular plant,7,6,1006-1025 (2014) Natella, F., Leoni, G., Maldini, M., Natarelli, L., Comitato, R., Schonlau, F., Virigil, F., Canali, R.,Absorbtion, Metabolisation And Effects At Transcriptome Level Of A Standardised French Oak Wood Extract Robuvit® In Healthy Volunteers: A Pilot Study., Journal of agricultural and food chemistry (2013) Pecorelli A., Leoni G., Cervellati F., Canali R., Signorini C. Leonicini S., Cortelazzo A. , De Felice C., Ciccoli L., Hayek J., Valacchi G. Genes Related to Mitochondrial Functions, Protein Degradation, and Chromatin Folding Are Differentially Expressed in Lymphomonocytes of Rett Syndrome Patients. Mediators of Inflammation (2013) Natella F., Leoni G., Maldini M., Natarelli L., Comitato R., Schonlau F., Virgili F., Canali R. Absorbtion, Metabolisation And Effects At Transcriptome Level Of A Standardised French Oak Wood Extract Robuvit® In Healthy Volunteers: A Pilot Study. JAFC (2013) Natella F., Maldini M. Leoni G. Scaccini C., Glucosinolates redox activities: Can they act as antioxidants?. Food chemistry (2013) 149,226-232 Ranaldi G, Ferruzza S, Canali R, Leoni G, Zalewski PD, Sambuy Y, Perozzi G, Murgia C. Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα. J Nutr Biochem. (2012) Sep 8. Floris, M., Raimondo, D., Leoni, G., Orsini, M., Marcatili, P. amd Tramontano, A. MAISTAS: a tool for automatic structural evaluation of alternative splicing products. Bioinformatics,79(5) 1513–1524 (2011) Leoni, G., Le Pera, L., Ferre', F., Raimondo, D., Tramontano, A. Coding potential of the products of alternative splicing in human.Genome Biology, 12:R9 doi:10.1186/gb-2011-12-1-r9 (2011) Leoni G, Comitato R, Canali R, Ambra R, Nesaretnam K, Virgili F. Tocotrienols activity in MCF-7 breast cancer cells: involvement of ERbeta signal transduction. Mol Nutr Food Res. 2010 May;54(5):669-78 (2010) Comitato R, Nesaretnam K, Leoni G, Ambra R, Canali R, Bolli A, Marino M, Virgili F. A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERβ signal transduction. AJP-Endoc. M. Aug;297(2):E427-37 (2009)