Twentyfive years ago, Cyrus Chothia and Arthur Lesk published a seminal paper (1) that illustrated the promise of quantitative computational analysis of biological data. We used the occasion of this anniversary to gather experts in the field of computational biology to discuss the many challenges that must be overcome if we are to realize the power of quantitative computational biology in the life sciences.
Annalisa Pastore and Anna Tramontano

(1) Chothia C, Lesk AM. The relation between the divergence of sequence and structure in proteins. EMBO J. 1986 Apr;5(4):823-6.

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Rita Casadio (I) Henriette Molinari (I)
Cyrus Chothia (UK) Alexei Murzin (UK)
Alexei Finkelstein (RU) Neri Niccolai (I)
Franca Fraternali (UK) Christine Orengo (UK)
Manuela Helmer-Citterich (I) Annalisa Pastore (UK)
Rachel Kolodny (IL) Torsten Schwede (CH)
Arthur Lesk (USA) Willie Taylor (UK)
Victor Lesk (UK) Pierandrea Temussi (I)
Michael Levitt (USA) Anna Tramontano (I)

Preliminary program

Department of Physics - Sapienza University - P.le A. Moro, 5 - 00185 Rome
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